How GLP-1 and amylin curb appetite through different pathways

Why pair two appetite hormones instead of pushing one harder? Because they don't fully overlap:

• GLP-1 (e.g. semaglutide) slows gastric emptying and acts on central satiety circuits via GLP-1 receptors.
• Amylin (e.g. cagrilintide) acts at the amylin receptor — a calcitonin-receptor/RAMP complex — contributing to satiety and glucagon suppression through partly distinct central and peripheral routes.

The hypothesis behind combinations is additivity: two complementary signals may produce more effect than either alone. Whether that bears out at scale is exactly what the Phase 3 programs test.

Mechanism ≠ outcome — a clean pathway story still has to prove itself in humans. Educational only.