Nootropic · Neuroprotection
Semax
Also known as: Met-Glu-His-Phe-Pro-Gly-Pro, ACTH(4-7) Pro-Gly-Pro, Methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline
A synthetic heptapeptide developed in Russia from an ACTH fragment, approved in Russia for ischemic stroke and used as a neuroprotective and nootropic agent.
Sign in to add to watchlistEvidence strength
Strength of human clinical evidence — A (strongest) to D (mostly preclinical). This reflects research maturity, not safety or suitability.
Vial Theory provides educational research summaries only. Content is not medical advice, diagnosis, treatment, dosing guidance, or individualized suitability screening. Regulatory status can change over time and varies by jurisdiction.
Key Takeaways
- ›Semax is a synthetic ACTH-fragment peptide approved in Russia for ischemic stroke and used as a nootropic.
- ›Unlike ACTH, it does not raise cortisol; proposed brain effects involve BDNF and NGF.
- ›Evidence is mostly Russian clinical studies and animal work; independent Western trials are essentially absent.
- ›It is not FDA/EMA-approved, and gray-market product differs from the regulated Russian formulation.
- ›Cognitive-enhancement claims exceed the evidence. Speak with a licensed healthcare professional.
What It Is
Semax is a synthetic heptapeptide derived from the 4-7 fragment of adrenocorticotropic hormone (ACTH) with three additional residues (Pro-Gly-Pro) added to stabilize the molecule against enzymatic degradation. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s-1990s.
Mechanistically, semax acts through multiple proposed pathways including modulation of BDNF and NGF (nerve growth factor) expression, effects on melanocortin receptors (consistent with its ACTH-derived structure), and broader influences on monoaminergic neurotransmission. Unlike its parent ACTH, semax does not stimulate the adrenal cortex or produce cortisol elevation, having been designed to retain neurotropic activity without the broader endocrine effects of ACTH itself. The compound is typically administered intranasally.
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Disclaimer: This content is for educational and research purposes only and is not medical advice. Always consult a licensed healthcare professional before making health-related decisions.