Nootropic · Anxiety · Immune
Selank
Also known as: TP-7, Threonyl-Lysyl-Prolyl-Arginyl-Prolyl-Glycyl-Proline
A synthetic heptapeptide developed in Russia as an anxiolytic, derived from the immune peptide tuftsin and used in Russian clinical practice for generalized anxiety.
Sign in to add to watchlistEvidence strength
Strength of human clinical evidence — A (strongest) to D (mostly preclinical). This reflects research maturity, not safety or suitability.
Vial Theory provides educational research summaries only. Content is not medical advice, diagnosis, treatment, dosing guidance, or individualized suitability screening. Regulatory status can change over time and varies by jurisdiction.
Key Takeaways
- ›Selank is a synthetic peptide (derived from tuftsin) approved in Russia for generalized anxiety disorder.
- ›Reports suggest anxiety relief without benzodiazepine-style sedation or dependence.
- ›Evidence is mostly small Russian studies; independent Western confirmation is essentially absent.
- ›It is not FDA/EMA-approved, and gray-market product differs from the regulated Russian formulation.
- ›Speak with a licensed healthcare professional before making any health-related decisions.
What It Is
Selank is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as an analog of the natural immune-related peptide tuftsin (a four-amino-acid fragment of immunoglobulin G). Selank's structure (Thr-Lys-Pro-Arg-Pro-Gly-Pro) extends tuftsin with three additional residues that confer stability against enzymatic degradation.
Mechanistically, selank has been characterized as having anxiolytic, mild stimulant, and immunomodulatory effects. The proposed mechanisms include modulation of GABAergic neurotransmission, serotonin metabolism, brain-derived neurotrophic factor expression, and effects on interleukin-6 and other immune signaling molecules. The compound is typically administered intranasally, which supports central nervous system exposure with less invasive dosing than injectable peptides.
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Disclaimer: This content is for educational and research purposes only and is not medical advice. Always consult a licensed healthcare professional before making health-related decisions.