Inflammation · Gut · Skin · Immune
KPV
Also known as: Lysine-Proline-Valine, α-MSH(11-13), C-terminal tripeptide of alpha-MSH
A three-amino-acid C-terminal fragment of alpha-MSH studied as an anti-inflammatory agent in inflammatory bowel disease and skin conditions, with most evidence still preclinical.
Sign in to add to watchlistEvidence strength
Strength of human clinical evidence — A (strongest) to D (mostly preclinical). This reflects research maturity, not safety or suitability.
Vial Theory provides educational research summaries only. Content is not medical advice, diagnosis, treatment, dosing guidance, or individualized suitability screening. Regulatory status can change over time and varies by jurisdiction.
Key Takeaways
- ›KPV is a three-amino-acid fragment of the natural hormone alpha-MSH with anti-inflammatory activity.
- ›Most evidence is preclinical (animal/cell); human data is limited to small pilot studies and case series.
- ›Online claims for gut, skin, and immune conditions exceed the human evidence.
- ›It is not FDA-approved, is often sold in unverified combination products, and long-term safety is unknown.
- ›Speak with a licensed healthcare professional before making any health-related decisions.
What It Is
KPV is a tripeptide consisting of lysine, proline, and valine (Lys-Pro-Val), corresponding to the C-terminal three residues of alpha-melanocyte-stimulating hormone (alpha-MSH). The fragment retains a portion of alpha-MSH's anti-inflammatory activity without acting at melanocortin receptors with the same affinity as the parent molecule.
Mechanistically, KPV is reported to exert anti-inflammatory effects through intracellular pathways including inhibition of NF-κB signaling and modulation of pro-inflammatory cytokine production, with some proposed activity at the PepT1 transporter that supports oral and intestinal-luminal effects. The compound is small enough to support oral, topical, and intracolonic administration in preclinical work, which has driven research interest in inflammatory bowel disease specifically.
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Disclaimer: This content is for educational and research purposes only and is not medical advice. Always consult a licensed healthcare professional before making health-related decisions.